Flowing toward potential CV therapeutic
It’s not a blockbuster cardiovascular drug – yet. But the pathway from bench to bedside is easy to see. In a recent eLife paper, Hanjoong Jo’s lab characterizes a “flow-kine”: a protein produced by...
View ArticleStraight to the heart: direct reprogramming creates cardiac “tissue” in mice
Bypassing stem cells, Emory scientists can now create engineered heart tissue by directly reprogramming connective tissue cells in mice. The findings could provide new avenues for a quest many...
View ArticleRegrowing adult heart muscle
In adulthood, our hearts generally can’t grow again in response to injury. Emory cardiology researchers Ahsan Husain and Nawazish Naqvi and their colleagues have been chipping away at this biological...
View ArticleSimpler, more portable ECGs: Emory experts hosting computing challenge
An electrocardiogram or ECG is a basic non-invasive diagnostic tool for cardiologists, which conventionally uses 12 electrodes to gather information about electrical signals in the heart and its...
View ArticleDissecting atherosclerosis at the single cell level: tasting each piece of a...
More than a decade ago, Hanjoong Jo and colleagues developed an elegant animal model allowing the dissection of atherosclerosis. It was the first to definitively show that disturbed patterns of blood...
View ArticleElevated troponin after exercise refines cardiac risk prediction
High levels of troponin, a sign of acute stress to the heart, in the blood reveal whether someone recently experienced a heart attack. Advances in testing have made it possible to detect much lower...
View ArticleModel of a sticky situation
Here’s an example of how 3D printing can be applied to pediatric cardiology. It’s also an example of how Georgia Tech, Emory and Children’s Healthcare of Atlanta all work together. Biomedical engineers...
View ArticleOvercoming cardiac pacemaker “source-sink mismatch”
Instead of complication-prone electronic cardiac pacemakers, biomedical engineers at Georgia Tech and Emory envision the creation of “biological pacemakers.” Hee Cheol Cho and colleagues have been...
View ArticleTake heart, Goldilocks — and get more sleep
Sleeping too little or too much increases the risk of cardiovascular events and death in those with coronary artery disease, according to a new paper from Emory Clinical Cardiovascular Research...
View ArticleFetal alcohol cardiac toxicity – in a dish
Alcohol exposure is known to perturb fetal heart development; half of all children with fetal alcohol syndrome have congenital heart defects, such as arrhythmias or structural abnormalities. Chunhui Xu...
View ArticleNogueira’s trailblazing work on stroke recognized
Neurologist Raul Nogueira’s clinical research on thrombectomy, a life-saving intervention after ischemic stroke, is getting recognition – in non-traditional ways. A group of Korean neurologists and...
View ArticleMapping shear stress in coronary arteries can help predict heart attacks
A heart attack is like an earthquake. When a patient is having a heart attack, it’s easy for cardiologists to look at a coronary artery and identify the blockages that are causing trouble. However,...
View ArticleMSCs: what’s in a name?
At a recent symposium of cellular therapies held by the Department of Pediatrics, we noticed something. Scientists do not have consistent language to talk about a type of cells called “mesenchymal stem...
View ArticleMini-monsters of cardiac regeneration
After a heart attack, cardiac muscle cells die because they are deprived of blood and oxygen. In an adult human, those cells represent a dead end. They can’t change their minds about what kind of cell...
View ArticleRacial disparities in a CV biomarker
Because circulating progenitor cells repair blood vessels, they are a measure of regenerative capacity in the cardiovascular system. Cardiologist Arshed Quyyumi, MD and his colleagues at Emory Clinical...
View ArticleStem cells driven into selective suicide
The term “stem cell” is increasingly stretchy. Orthopedic specialists have been using it when referring to bone marrow concentrate or platelet rich plasma, which are marketed as treatments for joint...
View ArticleBlue plate special: express delivery to the heart
The anti-arrhythmia drug amiodarone is often prescribed for control of atrial fibrillation, but can have toxic effects upon the lungs, eyes, thyroid and liver. Emory and Georgia Tech scientists have...
View ArticleDuel of the inflammatory master regulators: insights for drug discovery
Anti-inflammatory drugs such as dexamethasone can have harmful side effects on the skin, bones and metabolism. Structural biology research from Emory University School of Medicine has implications for...
View ArticleFor nanomedicine, cell sex matters
The biological differences between male and female cells may influence their uptake of nanoparticles, which have been much discussed as specific delivery vehicles for medicines. Vahid Serpooshan, PhD...
View ArticleElevated (but still low) troponin as a long term cardio biomarker
This weekend (March 10) at the American College of Cardiology meeting, data will emerge on whether expensive and much-discussed PCSK9 inhibitors can lower the risk of heart disease as much as they...
View Article